PHARMECEUTICAL RAW MATERIALS III

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Learning Outcomes

Will be able to Evaluate Central Nervous System Drugs From a Chemical Point of View.
• Classifies general anesthetics chemically. • Explains chemical classes of drugs. • Names inhalation anesthetics chemically. • Explains chemical structures of inhalation anesthetics. • Names solid general anesthetics chemically. • Explains the chemical structure of solid general anesthetics. • Explains the synthesis methods of solid general anesthetics. • Explains biotransformation of solid general anesthetics. • Names special combination of anesthetics chemically. • Explains the chemical structure of special combination anesthetics. • Explains the synthesis methods of special combination anesthetics. • Classifies local anesthetics chemically. • Explains chemical classes of drugs. • Names the ester derivatives chemically. • Explains chemical structure of ester derivatives. • Explains the interaction of ester derivatives with receptor. • Explains structure-activity relationships of ester derivatives. • Explains synthesis methods of ester derivatives. • Explains biotransformation of ester derivatives. • Names the amide derivatives chemically. • Explains chemical structures of amide derivatives. • Explains the interaction of amide derivatives with receptor. • Explains the structure-activity relationships of amide derivatives. • Explains synthesis methods of amide derivatives. • Explains biotransformation of amide derivatives. • Names other local anesthetics chemically. • Explains the chemical structures of other local anesthetics. • Explains the synthesis methods of other local anesthetics. • Classifies sedative and hypnotic drugs chemically. • Explains chemical classes of drugs. • Names alcohols chemically. • Explains the chemical structure of alcohols. • Explains synthesis methods of alcohols. • Names aldehydes chemically. • Explains the chemical structure of aldehydes. • Explains the synthesis methods of aldehydes. • Name the amides and ureites chemically. • Explains the chemical structure of amides and ureites. • Explains synthesis methods of amides and ureites. • Names Carbamic acid esters chemically. • Explains the chemical structure of carbamic acid esters. • Explains synthesis methods of carbamic acid esters. • Names barbiturates chemically. • Explains the chemical structure of barbiturates. • Explains the structure-activity relationships of barbiturates. • Explains the synthesis methods of barbiturates. • Explains biotransformation of barbiturates. • Names Piperidindiones chemically. • Explains the chemical structure of Piperidindiones. • Explains the synthesis methods of Piperidindiones. • Explains the biotransformation of Piperidindiones. • Names the 4-quinazolinone derivatives chemically. • Explains the chemical structures of 4-quinazolinone derivatives. • Explains synthesis methods of 4-quinazolinone derivatives. • Names benzodiazepines chemically. • Explains the chemical structure of benzodiazepines. • Explains the synthesis methods of benzodiazepines. • Explains biotransformation of benzodiazepines. • Names other sedative and hypnotic compounds chemically. • Explains the chemical structures of other sedative and hypnotic compounds. • Explains the synthesis methods of other sedative and hypnotic compounds. • Explains chemical classes of drugs. • Names benzodiazepine derivatives chemically. • Explains the chemical structure of benzodiazepine derivatives. • Explains the structure-activity relationships of benzodiazepine derivatives. • Explains synthesis methods of benzodiazepine derivatives. • Explains biotransformation of benzodiazepine derivatives. • Names Propandiol dicarbamate derivatives chemically. • Explains the chemical structure of propanediol dicarbamate derivatives. • Explains biotransformation of propanediol dicarbamate derivatives. • Names diphenylmethane derivatives chemically. • Explains the chemical structure of diphenylmethane derivatives. • Explains synthesis methods of diphenylmethane derivatives. • Explains biotransformation of diphenylmethane derivatives. • Names cyclopirolone derivatives chemically. • Explains the chemical structure of cyclopyrolone derivatives. • Explains the synthesis methods of cyclopyrolone derivatives. • Names other tranquilizer compounds tranquilizer. • Explains the chemical structures of other tranquilizer compounds. • Explains the synthesis methods of other tranquilizer compounds. • Explains biotransformation of other tranquilizer compounds. • Classifies neuroleptic drugs chemically. • Explains chemical classes of drugs. • Names phenothiazine derivatives chemically. • Explains the chemical structure of phenothiazine derivatives. • Explains the regions of phenothiazine derivatives that interact with the receptor. • Explains the structure-activity relationships of phenothiazine derivatives. • Explains the synthesis methods of phenothiazine derivatives. • Explains the biotransformation of phenothiazine derivatives. • Names the thioxantene derivatives chemically. • Explains the chemical structure of thioxanthene derivatives. • Explains structure-activity relationships of thioxanthene derivatives. • Explains synthesis methods of thioxanthene derivatives. • Explains biotransformation of thioxanthene derivatives. • Names dibenzodiazepine and dibenzooksepine derivatives chemically. • Explains the chemical structure of dibenzodiazepine and dibenzooksepine derivatives. • Explains the structure-activity relationships of dibenzodiazepine and dibenzooksepine derivatives. • Explains synthesis methods of dibenzodiazepine and dibenzooksepine derivatives. • Explains biotransformation of dibenzodiazepine and dibenzooksepine derivatives. • Names fluorobutyrofenone derivatives chemically. • Explains the chemical structure of fluorobutyrofenone derivatives. • Explains the structure-activity relationships of fluorobutyrofenone derivatives. • Explains synthesis methods of fluorobutyrofenone derivatives. • Explains the biotransformation of fluorobutyrofenone derivatives. • Names diphenylbutylpiperidine derivatives chemically. • Explains chemical structures of diphenylbutylpiperidine derivatives. • Explains synthesis methods of diphenylbutylpiperidine derivatives. • Explains biotransformation of diphenylbutylpiperidine derivatives. • Names benzamides chemically. • Explains the chemical structure of benzamides. • Explains synthesis methods of benzamides. • Explains the biotransformation of benzamides. • Names indole derivatives and isosteres chemically. • Explains chemical structures of indole derivatives and isosteres. • Explains synthesis methods of indole derivatives and isosteres. • Explains biotransformation of indole derivatives and isosteres. • Names various neuroleptic compounds chemically. • Explains the chemical structure of various neuroleptic compounds. • Explains the synthesis methods of various neuroleptic compounds. • Explains the biotransformation of various neuroleptic compounds. • Names reserpine and other Rauwolfia alkaloids chemically. • Explains the chemical structure of reserpine and other Rauwolfia alkaloids. • Explains biotransformation of reserpine and other Rauwolfia alkaloids. • Clasifies antidepressant and antimanic drugs chemically. • Explains chemical classes of drugs. • Names tricyclic antidepressants chemically. • Explains the chemical structure of tricyclic antidepressants. • Explains the structure-activity relationships of tricyclic antidepressants. • Explains the synthesis methods of tricyclic antidepressants. • Explains biotransformation of tricyclic antidepressants. • Names tetracyclic antidepressants chemically. • Explains chemical structures of tetracyclic antidepressants. • Explains the synthesis methods of tetracyclic antidepressants. • Explains biotransformation of tetracyclic antidepressants. • Names monoamine oxidase inhibitors chemically. • Explains chemical structures of monoamine oxidase inhibitors. • Explains synthesis methods of monoamine oxidase inhibitors. • Explains the biotransformation of monoamine oxidase inhibitors. • Explains the chemical structures of lithium salts. • Explains the synthesis methods of lithium salts. • Names other antidepressant and antimanic drugs chemically. • Explains the chemical structure of other antidepressant and antimanic drugs. • Explains the synthesis methods of other antidepressant and antimanic drugs. • Explains the biotransformation of other antidepressant and antimanic drugs. • Classifies antiepileptic drugs chemically. • Explains chemical classes of drugs. • Names compounds bearing urea chemically. • Explains the chemical structure of the compounds bearing urea. • Explains the synthesis methods of urea-bearing compounds. • Explains biotransformation of urea-bearing compounds. • Names benzodiazepines chemically. • Explains the chemical structure of benzodiazepines. • Explains the chemical structure of secondary and tertiary alcohols. • Explains the synthesis methods of secondary and tertiary alcohols. • Names dibenzazepine derivatives chemically. • Explains the chemical structure of dibenzazepine derivatives. • Explains synthesis methods of dibenzazepine derivatives. • Explains biotransformation of dibenzazepine derivatives. • Names valproic acid derivatives chemically. • Explains chemical structure of valproic acid derivatives. • Explains the synthesis methods of valproic acid derivatives. • Explains the biotransformation of valproic acid derivatives. • Names GABA names analogs chemically. • Explains the chemical structure of GABA analogs. • Explains the synthesis methods of GABA analogs. • Names other antiepileptic drugs chemically. • Explains the chemical structure of other antiepileptic drugs. • Explains the structure-activity relationships of other antiepileptic drugs. • Explains the synthesis methods of other antiepileptic drugs. • Explains the biotransformation of other antiepileptic drugs. • Classifies centrally acting muscle relaxers chemically. • Explains chemical classes of drugs. • Names propandiol derivatives chemically. • Explains the chemical structure of propanediol derivatives. • Explains the synthesis methods of propanediol derivatives. • Names benzoxazole derivatives chemically. • Explains the chemical structure of benzoxazole derivatives. • Explains synthesis methods of benzoxazole derivatives. • Names benzodiazepines chemically. • Explains the chemical structure of benzodiazepines. • Explains the synthesis methods of benzodiazepines. • Names other centrally acting muscle relaxant drugs chemically. • Explains the chemical structures of other centrally acting muscle relaxant drugs. • Explains the methods of synthesis of other central acting muscle drugs. • Classifies analeptic drugs as chemically. • Explains chemical classes of drugs. • Names breathing stimulants chemically. • Explains the chemical structure of respiratory stimulants. • Explains synthesis methods of respiratory stimulants. • Names the convulsant stimulators chemically. • Explains chemical structure of convulsant stimulants. • Explains the synthesis methods of convulsant stimulators. • Names the psychomotor stimulants chemically. • Explains the chemical structure of psychomotor stimulants. • Explains the synthesis methods of psychomotor stimulants. • Names adrenergic stimulants chemically. • Explains the chemical structure of adrenergic stimulants. • Explains the structure-activity relationships of adrenergic stimulants. • Explains the synthesis methods of adrenergic stimulants. • Categorizes psychomimetic drugs chemically. • Explains chemical classes of drugs. • Names indolalkylamines chemically. • Explains the chemical structure of indolalkylamines. • Names phenyalkylamines chemically. • Explains the chemical structure of phenylalkylamines. • Names cannabinoids chemically. • Explains the chemical structures of cannabinoids. • Classifies narcotic analgesics chemically. • Explains chemical classes of drugs. • Names morphine and its derivatives chemically. • Explains chemical and stereochemical structures of morphine and its derivatives. • Explains structure-effect relationships of morphine and its derivatives. • Explains the synthesis methods of morphine and its derivatives. • Explains the biotransformation of morphine and its derivatives. • Names oripavin and its derivatives chemically. • Explains the chemical structure of oripavin and its derivatives. • Names morphinan and its derivatives chemically. • Explains the chemical structure of morphine and its derivatives. • Names meperidine and its derivatives chemically. • Explains the chemical structure of meperidine and its derivatives. • Explains the structure-activity relationships of meperidine and its derivatives. • Explains the synthesis methods of meperidine and its derivatives. • Explains biotransformation of meperidine and its derivatives. • Names benzomorphan derivatives chemically. • Explains the chemical structure of benzomorphan derivatives. • Names methadone and its derivatives chemically. • Explains the chemical structure of methadone and its derivatives. • Explains the synthesis methods of methadone and its derivatives. • Names different types of narcotic analgesics chemically. • Explains the chemical structure of various types of narcotic analgesics. • Explains the synthesis methods of various types of narcotic analgesics. • Names a variety of narcotic antagonists chemically. • Explains chemical classes of drugs. • Classifies nonsteroidal antiinflammatory chemically. • Explains chemical classes of drugs.. • Names the salicylic acid derivatives chemically. • Explains chemical structures of salicylic acid derivatives. • Describes the interaction of salicylic acid derivatives with enzyme. • Explains the structure-activity relationships of salicylic acid derivatives. • Explains synthesis methods of salicylic acid derivatives. • Explains biotransformation of salicylic acid derivatives. • Names p-Aminophenol derivatives chemically. • Explains the chemical structure of p-aminophenol derivatives. • Explains the structure-activity relationships of p-aminophenol derivatives. • Explains the synthesis methods of p-Aminophenol derivatives. • Explains the biotransformation of p-Aminophenol derivatives. • Names 5-pyrazolone and 3,5-pyrazolidinedione chemically. • Explains the chemical structures of 5-pyrazolone and 3,5-pyrazolidinedione. • Explains the structure-activity relationships of 5-pyrazolone and 3,5-pyrazolidinedione derivatives. • Explains the synthesis methods of 5-pyrazolone and 3,5-pyrazolidinedione derivatives. • Explains the biotransformation of 5-pyrazolone and 3,5-pyrazolidinedione derivatives. • Names N-Arylantranylic acid derivatives chemically. • Explains the chemical structure of N-Arylantranylic acid derivatives. • Describes the structure-activity relationships of N-Arylantranylic acid derivatives. • Explains synthesis methods of N-Arylantranylic acid derivatives. • Explains biotransformation of N-Arylantranylic acid derivatives. • Names aryl, heteroarylacetic and propionic acid derivatives chemically. • Explains the chemical structure of the aryl, heteroaryl and propionic acid derivatives. • Explains the structure-activity relationships of aryl, heteroaryl and propionic acid derivatives. • Explains the synthesis methods of aryl, heteroaryl and propionic acid derivatives. • Explains biotransformation of aryl, heteroaryl and propionic acid derivatives. • Names selective COX-2 inhibitors chemically. • Describes the chemical structures of selective COX-2 inhibitors. • Describes the interaction of selective COX-2 inhibitors with enzyme. • Describes the structure-activity relationships of selective COX-2 inhibitors. • Describes the synthesis methods of selective COX-2 inhibitors. • Describes the biotransformation of selective COX-2 inhibitors. • Classifies the drugs used in the treatment of Alzheimer's disease. • Explains chemical classes of drugs. • Names the drugs used in the treatment of Alzheimer's disease, chemically. • Explains the chemical structure of drugs used in the treatment of Alzheimer's disease. • Explains the synthesis methods of drugs used in the treatment of Alzheimer's disease. • Classifies antiparkinson drugs chemically. • Explains chemical classes of drugs. • Names antiparkinsonian drugs chemically. • Explains the chemical structure of antiparkinson drugs. • Explains synthesis methods of antiparkinson drugs.
Will be able to Evaluate Herbal Drugs Related to Central Nervous System.
• Lists local anesthetic drugs. • Describes the general characteristics of local anesthetic drugs. • Explains the chemical composition of local anesthetic drugs. • Explains the use and dosage of local anesthetic drugs. • Explains the importance of local anesthetic drugs. • Lists the neuromuscular blocking drugs. • Lists the general characteristics of neuromuscular blocking drugs. • Explains the chemical composition of neuromuscular blocking drugs. • Explains the use and dose of neuromuscular blocking drugs. • Explains the issues to be considered during the use of neuromuscular blocking drugs. • Lists central acting muscle relaxant drugs. • Lists the general features of central acting muscle relaxant drugs. • Explains the chemical composition of central acting muscle relaxant drugs. • Explains the use and dose of central acting muscle relaxant drugs. • Explains the factors that should be considered during the use of central acting muscle relaxant drugs. • Lists the drugs with hypnosed drugs. • Lists the general characteristics of hypnosedive drugs. • Explains the chemical composition of hypnosed drugs. • Determines the dosage of hypnosed drugs. • Explains the issues to be considered during the use of hypnosedive drugs. • Lists the neuroleptic drugs. • Lists the general characteristics of neuroleptic drugs. • Explains the chemical compounds of neuroleptic drugs. • Determines the dosage of neuroleptic drugs. • Explains the issues to be considered during the use of neuroleptic drugs. • Lists the drugs used in mood disorders. • Lists the general characteristics of drugs used in mood disorders. • Explains the chemical composition of drugs used in mood disorders. • Determines the dosage of drugs used in mood disorders. • Explains the issues to be considered during the use of drugs used in mood disorders. • Lists the drugs used in mood disorders. • Lists the general characteristics of drugs used in mood disorders. • Explains the chemical composition of drugs used in mood disorders. • Determines the dosage of drugs used in mood disorders. • Explains the issues to be considered during the use of drugs used in mood disorders. • Explains the opioids from which they are obtained. • Lists the general properties of the opioids from which they are obtained. • Explains the chemical properties of opioids. • Explains the methods of obtaining opioids from drogs. • Lists the drugs used against rheumatoid arthritis. • Describes the general characteristics of drugs used against rheumatoid arthritis. • Explains the chemical composition of drugs used against rheumatoid arthritis. • Determines the dosage of drugs used against rheumatoid arthritis. • Explains the issues that should be considered during the use of drugs used against rheumatoid arthritis. • Lists the drugs used in gout treatment. • Lists the general characteristics of drugs used in gout treatment. • Explains the chemical composition of drugs used in gout. • Determines the dosage of drugs used in gout treatment. • Explains the issues to be considered during the use of drugs used in gout treatment. • Lists the anti-inflammatory drugs. • Lists the general characteristics of anti-inflammatory drugs. • Explains the chemical composition of anti-inflammatory drugs. • Determines the dosage of anti-inflammatory drugs. • Explains the issues to be considered during the use of anti-inflammatory drugs. • Lists the central nervous system stimulant drugs. • Lists the general features of central nervous system stimulant drugs. • Explains the chemical composition of central nervous system stimulants. • Determines the dosage of central nervous system stimulant drugs. • Explains the central nervous system stimulants related points that should be considered during the use of drugs. • Lists antiepileptic drugs. • Lists the general characteristics of antiepileptic drugs. • Explains chemical compounds of antiepileptic drugs. • Determines the dosage and dosage of antiepileptic drugs. • Explains the issues to be considered during the use of antiepileptic drugs. • Lists the drugs used in the treatment of Parkinson's disease and other movement disorders. • Lists the general characteristics of drugs used in the treatment of Parkinson's disease and other movement disorders. • Explains the chemical composition of drugs used in the treatment of Parkinson's disease and other movement disorders. • Determines the dosage and dosage of drugs used in the treatment of Parkinson's disease and other movement disorders. • Explains the issues to be considered during the use of drugs used in the treatment of Parkinson's disease and other movement disorders. • Lists the general characteristics of drugs used in the treatment of Alzheimer's disease. • Explains the chemical composition of drugs used in the treatment of Alzheimer's disease. • Determines the dosage of drugs used in the treatment of Alzheimer's disease. • Explains the issues to be considered during the use of drugs in the treatment of Alzheimer's disease.
Will be able to Evaluate Quality Control Practices for Some Herbal Drugs; Synthesis, Analysis, Quality Control and Spectroscopy Practices of Some Pharmaceutical Compounds Related to Central Nervous System.
• Determines the appropriate method for synthesis of the target compound. • Explains synthesis method of target compound. • Explains the reaction equation and mechanism of compound synthesis. • Lists the chemicals required for the synthesis of the target compound. • Explains the properties of chemical substances and their intended use for the synthesis of the target compound. • Describes the properties and uses of devices required for synthesis of target compound. • Explains reaction conditions of synthesis of target compound. • Synthesizes the target compound. • Terminates the reaction of the target compound according to the result of the TAC application. • Applies the filtration process to remove the synthesis product from the reaction medium. • Applies extraction process to remove the synthesis product from the reaction medium. • Explains the physical and chemical properties of the synthesis product. • Calculates the theoretical, practical and percent yield of the synthesis product. • Determines the suitable recrystallization solvent for the synthesis product. • Describes recrystallization of the synthesis product • Recrystallizes the synthesis product. • Lists the estimated IR data of the compounds of pharmaceutical importance. • Determines which functional groups belong to the bands observed in the IR spectra of the compounds of pharmaceutical importance. • Evaluates the structure by interpreting the IR spectra of the compounds of pharmaceutical importance. • Lists the estimated 1H NMR data of the compounds of pharmaceutical importance. • Determines the protons belong to the peaks observed in the 1H NMR spectra of the compounds of pharmaceutical importance. • Specifies the structure by interpreting the 1H NMR spectra of the compounds of pharmaceutical importance. • Lists the estimated MS data of pharmaceutical importance compounds. • Determines the parts belong to the peaks observed in the mass spectra of the compounds of pharmaceutical importance. • Determines molecular ion peak in mass spectra of compounds of pharmaceutical importance. • Determines the basic peak in the mass spectra of compounds of pharmaceutical importance. • Interprets mass spectra of compounds of pharmaceutical importance. • Evaluates the structure of an unknown molecule by interpreting IR, NMR and Mass spectra and other techniques of pharmaceutical importance compounds. • Distinguishes the sample by color, smell, taste and appearance. • Determines the melting point of the sample. • Determines the resolution class of sample. • Applies the burning test to the sample and interprets the results. • Determines the presence of nitrogen in the sample. • Detects the presence of sulfur in the sample. • Detects the presence of halogen in the sample. • Determines whether it is acidic, basic or neutral. • Distinguishes recognition tests of functional groups in the sample. • Explains the recognition tests of the functional groups in the sample. • Applies functional group recognition tests to the sample. • Identifies the specific diagnostic reaction that can be applied to the sample. • Performs a sample-specific diagnostic reaction. • Lists the titrimetric methods that can be applied to the sample. • Determines the purity of the sample by using the asymmetric method. • Determines the purity of the sample by using the alkalimetric method. • Determines the purity of the sample by using a nitriteometric method. • Determines the purity of the sample using the iodimetric method. • Detects the purity of the sample by spectrophotometric method specified in the pharmacopoeia.
Will be able to Evaluate Quality Control Practices for Some Herbal Drugs Related to Central Nervous System.
• Applies macroscopic methods to a selected drug. • Applies organoleptic methods to a selected drug. • Evaluates the results of macroscopic and organoleptic analysis for a selected drug. • Lists the appropriate reagents in order to examine a selected stain by microscopic methods. • Uses the assignment key to examine a selected micrograph by microscopic methods. • Examines a selected drug microscopically. • Evaluates the results of a microscopic examination. • Explains the foreign matter quantification method for a selected drug. • Evaluates the results in terms of limit values by calculating the amount of foreign matter for a selected drug. • Lists the physicochemical methods required for a selected drug. • Explains the process steps of physicochemical methods for a selected drug. • Determines the results of the physicochemical method required for a selected drug. • Compares the results of the physicochemical method required for a selected drug with the limit values. • Lists the appropriate extraction methods for target active substances in a selected drug. • Describes the extraction steps for a selected drug. • Applies the appropriate extraction method for the target active substances in a selected drug. • Lists the appropriate diagnostic reactions for the target active substances in a selected drug. • Describes the processing steps for the appropriate diagnostic reactions for the target active substances in a selected drug. • Evaluates the appropriate diagnostic reaction results for target active substances in a selected drug. • Lists the appropriate chromatographic analysis methods for target active substances in a selected drug. • Describes the appropriate chromatographic analysis steps for the target active substances in a selected drug. • Applies suitable chromatographic methods for target active substances in a selected drug. • Evaluates the results of suitable chromatographic methods for target active substances in a selected drug. • Lists the adulteration determinations indicated in the Pharmacope for a selected drug. • Describes the process steps to determine adulteration in a selected drug. • Determines adulterations in a selected drug. • Lists the pharmacognosy methods in pharmacopoeia for a selected drug. • Explains the process steps of pharmacognosy methods for a selected drug. • Applies the pharmacognosy methods in pharmacotherapy for a selected drug. • Compares the results obtained for a selected drug to the pharmacopeia. • Interprets and evaluates all the results obtained for a selected drug.