PHARMECEUTICAL RAW MATERIALS II

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Learning Outcomes

Will be able to Evaluate Autonomic Nervous System Drugs From a Chemical Point of View.
• Categorizes sempotomimetics chemically. • Explains the chemical class of active substances. • Names catecholamine derivatives chemically. • Explains the chemical structure of catecholamine derivatives. • Explains the regions of the interaction of catecholamine derivatives with the receptor. • Explains the structure-activity relationships of catecholamine derivatives. • Explains the synthesis methods of catecholamine derivatives. • Explains the biotransformation of catecholamine derivatives. • Names the imidazole derivatives chemically. • Explains chemical structures of imidazole derivatives. • Explains synthesis methods of imidazoline derivatives. • Names aliphatic amines and acetamide derivatives chemically. • Explains the chemical structure of aliphatic amine and acetamide derivatives. • Explains synthesis methods of aliphatic amine and acetamide derivatives. • Categorizes sympatholytics chemically. • Explains the chemical class of active substances. • Names Ergot alkaloids chemically. • Explains the chemical structure of Ergot alkaloids. • Explains synthesis methods of ergot alkaloids. • Explains the biotransformation of ergot alkaloids. • Names betahaloalkylamine derivatives chemically. • Explains the chemical structure of betahaloalkylamine derivatives. • Explains the structure-activity relationships of betahaloalkylamine derivatives. • Explains the synthesis methods of betahaloalkylamine derivatives. • Names the imidazole derivatives chemically. • Explains chemical structures of imidazole derivatives. • Explains synthesis methods of imidazoline derivatives. • Names beta-blockers chemically. • Explains the chemical structure of beta blockers. • Explains the interaction of beta-blockers with receptor. • Explains the structure-effect relationships of beta-blockers. • Explains the synthesis methods of beta blockers. • Explains biotransformation of beta blockers. • Classifies parasympathomimetics chemically • Explains the chemical class of active substances. • Names cholinergic agonists chemically. • Explains the chemical structure of cholinergic agonists. • Explains the regions of cholinergic agonists that interact with the receptor. • Explains the structure-effect relationships of cholinergic agonists. • Explains synthesis methods of cholinergic agonists. • Names anticholinesterases chemically. • Explains the chemical structure of anticholinesterases. • Explains synthesis methods of anticholinesterases. • Explains biotransformation of anticholinesterases. • Explains the interaction areas of anticholinesterases with enzyme. • Names anticholinesterases chemically • Explains synthesis methods of anticholinesterases. • Explains the interaction areas of anticholinesterases with enzyme. • Classifies the parasympatholytics as chemical. • Explains the chemical class of active substances. • Names Solaneceae alkalolids and synthetic derivatives chemically. • Explains the chemical structure of Solaneceae alkolids and synthetic derivatives. • Explains the structure-activity relationships of Solaneceae alkalolids and synthetic derivatives. • Explains the synthesis methods of Solaneceae alkalolids and synthetic derivatives. • Explains biotransformation of solaneceae alkalolids and synthetic derivatives. • Names aminoalkol esters chemically. • Explains the chemical structure of aminoalcohol esters. • Explains structure-activity relationships of aminoalcohol esters. • Explains the synthesis methods of aminoalcohol esters. • Names the aminoalcohol ethers chemically. • Explains the chemical structure of aminoalcohol ethers. • Explains structure-activity relationships of aminoalcohol ethers. • Explains synthesis methods of aminoalcohol ethers. • Names the aminoalcohols chemically. • Explains the chemical structure of aminoalcohols. • Explains structure-activity relationships of aminoalcohols. • Explains the synthesis methods of aminoalcohols. • Explains the biotransformation of aminoalcohols. • Names aminoamides and other synthetic derivatives chemically. • Explains the structure-activity relationships of aminoamides and other synthetic derivatives. • Explains the synthesis methods of aminoamides and other synthetic derivatives. • Names papaver alkaloids and synthetic derivatives chemically. • Explains the chemical structure of Papaver alkolids and synthetic derivatives. • Explains the synthesis methods of Papaver alkaloids and synthetic derivatives. • Explains the biotransformation of Papaver alkalolids and synthetic derivatives. • Papaver alkolids and synthetic derivatives. • Names the neuromuscular blocking drugs chemically.. • Explains the chemical structure of neuromuscular blocking drugs. • Explains synthesis methods of neuromuscular blocking drugs.
Will be able to Evaluate Herbal Drugs Related to Autonomic Nervous System.
• Lists the parasympathomimetic drugs. • Describes the general characteristics of parasympathomimetic drugs. • Explains the chemical composition of parasympathomimetic drugs. • Explains the use and dosage of parasympathomimetic drugs. • Explains the issues to be considered in the use of parasympathomimetic drugs. • Lists mushrooms that cause poisoning. • Explains the active compounds of fungi that cause rapid poisoning. • Lists late mushrooms. • Explains the active compounds of late poisoning fungi. • Lists anticholinesterase-active drugs. • Lists the general properties of anticholinesterase-acting drugs. • Explains the chemical composition of anticholinesterase active drugs. • Explains the use and dose of anticholinesterase drugs. • Explains the issues to be considered in the use of anticholinesterase drugs. • Categorizes parasympatholytic drugs. • Describes the general features of parasympatholytic drugs. • Explains the chemical composition of parasympatholytic drugs. • Explains the use and dosage of parasympatholytic drugs. • Explains the issues to be considered in the use of parasympatholytic drugs. • Categorizes sympathomimetic drugs. • Lists the general features of sympathomimetic drugs. • Explains chemical composition of sympathomimetic drugs. • Explains the use and dosage of sympathomimetic drugs. • Explains the issues to be considered in the use of sympathomimetic drugs. • Categorizes sympatholytic effective drugs. • Lists the general features of sympatholytic drugs. • Explains the chemical composition of drugs with sympatholytic effect. • Explains the use and dosage of sympatholytic drugs. • Explains the issues to be considered in the use of sympatholytic drugs. • Lists the drugs with active substance nicotine. • Explains the use and dosage of nicotine drugs. • Explains the factors that should be considered in the use of the active substance nicotine drugs • Classifies other ganglion-stimulating drugs. • Lists effective compounds of other ganglion-stimulating drugs. • Explains the dosage and dosage of other ganglion-stimulating drugs. • Explains the issues that should be considered in the use of other ganglion-stimulating drugs.
Will be able to Evaluate Cardiovascular and Urinary Systems Drugs From a Chemical Point of View.
• Classifies the drugs used in heart failure chemically. • Explains chemical classes of drugs. • Names the cardiac glycosides chemically. • Explains the chemical structure of cardiac glycosides. • Describes the regions of cardiac glycosides that interact with the receptor. • Explains structure-activity relationships of cardiac glycosides. • Names the Xanthine derivatives. • Explains chemical structures of xanthine derivatives. • Explains the synthesis methods of xanthine derivatives. • Explains the biotransformation of xanthine derivatives. • Names carbonic anhydrase inhibitors. • Explains the chemical structure of carbonic anhydrase inhibitors. • Explains the synthesis methods of carbonic anhydrase inhibitors. • Explains structure-activity relationships of carbonic anhydrase inhibitors. • Explains the interaction of carbonic anhydrase inhibitors with enzyme. • Names diuretics chemically. • Explains the chemical structure of mercury diuretics. • Explains the synthesis methods of mercury diuretics. • Explains the structure-effect relationships of mercurial diuretics. • Explains the interaction regions of mercurial diuretics with receptor. • Names the crimp diuretics chemically. • Explains chemical structures of crimp diuretics. • Explains synthesis methods of crimp diuretics. • Explains the structure-effect relations of crimp diuretics. • Explains biotransformation of crimp diuretics. • Names thiazide group and thiazide-like sulfonamide diuretics chemically. • Explains chemical structure of thiazide group and thiazide like sulfonamide diuretics. • Explains synthesis methods of thiazide group and thiazide like sulfonamide diuretics. • Explains the structure-activity relationships of thiazide group and thiazide-like sulfonamide diuretics. • Explains biotransformation of thiazide group and thiazide like sulfonamide diuretics. • Explains the chemical structure of aldesterone antagonists. • Names derivatives of cycloamidine chemically. • Explains the chemical structure of the derivatives of Cycloamide. • Explains the synthesis methods of the derivatives of Cycloamide. • Explains biotransformations of cycloamides derivatives • Names ACE inhibitors chemically. • Explains the chemical structure of ACE inhibitors chemically. • Describes the interaction of ACE inhibitors with enzyme. • Describes the synthesis methods of ACE inhibitors. • Names phosphodiesterase inhibitors chemically. • Explains the chemical structure of phosphodiesterase inhibitors. • Explains synthesis methods of phosphodiesterase inhibitors. • Classifies antiarrhythmic drugs chemically. • Explains chemical classes of drugs. • Names antiarrhythmic drugs chemically. • Explains chemical structures of tachyarrhythmic drugs. • Explains the synthesis methods of tachyarrhythmic drugs. • Explains the structure-effect relationships of tachyarrhythmic drugs. • Explains biotransformation of tachyarrhythmic drugs. • Names Bradyarithmic drugs chemically. • Explains the chemical structure of bradyarrhythmic drugs. • Explains the synthesis methods of bradyarrhythmic drugs. • Classifies antihypertensive drugs chemically. • Explains chemical classes of drugs. • Names nitrates and nitrites chemically. • Explains the chemical structure of nitrates and nitrites. • Explains the synthesis methods of nitrates and nitrites. • Explains the biotransformation of nitrates and nitrites. • Names 1,4-dihydropyridine derivatives chemically. • Explains the chemical structure of 1,4-dihydropyridine derivatives. • Explains synthesis methods of 1,4-dihydropyridine derivatives. • Explains biotransformation of 1,4-dihydropyridine derivatives. • Explains structure-activity relationships of 1,4-dihydropyridine derivatives. • Names verapamil analogs chemically. • Explains the chemical structures of Verapamil analogues. • Explains the synthesis methods of Verapamil analogues. • Explains the biotransformation of Verapamil analogs. • Names diphenylalkylamines chemically. • Explains chemical structures of diphenylalkylamines. • Explains the synthesis methods of diphenylalkylamines. • Names various antianginal drugs. • Explains the chemical structure of various antianginal drugs. • Explains the synthesis methods of various antianginal drugs. • Explains biotransformations of various antianginal drugs. • Classifies antihypertensive drugs chemically. • Explains chemical classes of drugs. • Names direct-acting vasodilators. • Explains chemical structures of direct acting vasodilators. • Explains synthesis methods of direct acting vasodilators. • Names the beta-adrenergic receptor antagonists chemically. • Explains the chemical structure of beta-adrenergic receptor antagonists. • Explains the synthesis methods of beta adrenergic receptor antagonists. • Names calcium antagonists chemically. • Explains the chemical structure of calcium antagonists. • Explains the synthesis methods of calcium antagonists. • Names different types of vasodilator drugs chemically. • Explains the chemical structure of various structured vasodilator drugs. • Explains the synthesis methods of various structured vasodilator drugs. • Explains biotransformation of various vasodilator drugs. • Classifies antihypertensive drugs chemically. • Explains chemical classes of drugs. • Names the central sympatholytic drugs chemically. • Explains the chemical structure of central sympatholytic drugs. • Explains the synthesis methods of central sympatholytic drugs. • Explains biotransformation of central sympatholytic drugs. • Names Imidazoline derivatives chemically. • Explains chemical structures of imidazoline derivatives. • Explains synthesis methods of imidazoline derivatives. • Explains biotransformation of imidazoline derivatives. • Names Reserpine derivatives chemically. • Explains the chemical structure of reserpine derivatives. • Explains synthesis methods of reserpine derivatives. • Explains biotransformation of reserpine derivatives. • Names Guanitidine derivatives chemically. • Explains chemical structures of guanitidine derivatives. • Explains the synthesis methods of guanitidine derivatives. • Explains the biotransformation of guanitidine derivatives. • Names the aminokinazoline derivatives chemically. • Explains the chemical structure of aminokinazoline derivatives. • Explains the synthesis methods of aminokinazoline derivatives. • Explains biotransformations of aminokinazoline derivatives. • Names indole derivatives chemically. • Explains chemical structures of indole derivatives. • Explains synthesis methods of indole derivatives. • Explains biotransformation of indole derivatives. • Names vasodilators chemically. • Explains the chemical structures of arterial vasodilators. • Explains the synthesis methods of arterial vasodilators. • Explains biotransformations of arterial vasodilators. • Names arterial and venous vasodilators chemically. • Explains the chemical structure of arterial and venous vasodilators. • Describes the synthesis methods of arterial and venous vasodilators. • Explains biotransformation of arterial and venous vasodilators. • Names angiotensin II antagonists chemically. • Explains the chemical structure of angiotensin II antagonists. • Explains the synthesis methods of angiotensin II antagonists. • Explains biotransformation of angiotensin II antagonists. • Describes the sites of angiotensin II antagonists interaction with the receptor. • Names phenylethylamines chemically. • Explains the chemical structure of phenylethylamines. • Classifies antihyperlipidemic drugs chemically. • Explains chemical classes of drugs. • Names of hydroxymethylglutaryl-coenzyme a (HMGCoA) reductase inhibitors. • Explains the chemical structure of HMGCoA reductase inhibitors. • Explains the synthesis methods of HMGCoA reductase inhibitors. • Explains the biotransformation of HMGCoA reductase inhibitors. • Explains the interaction of HMGCoA reductase inhibitors with enzyme. • Names fibrate derivatives chemically. • Explains chemical structures of fibrate derivatives. • Explains synthesis methods of fibrate derivatives. • Explains biotransformation of fibrate derivatives. • Names nicotinic acid derivatives chemically. • Explains the chemical structure of nicotinic acid derivatives. • Explains the synthesis methods of nicotinic acid derivatives. • Names other drugs that reduce the synthesis of lipoproteins, chemically. • Explains the chemical structure of other drugs that reduce the synthesis of lipoproteins. • Explains the biotransformation of other drugs that reduce the synthesis of lipoproteins. • Explains the chemical structure of bile acid binding drugs. • Names other drugs that bind bile acid, chemically. • Explains the chemical structure of bile acid binding drugs. • Explains the synthesis methods of other bile acid-binding drugs. • Names antivaris drugs, chemically. • Explains the chemical structure of antivaris drugs. • Explains the synthesis methods of antivaris drugs. • Classifies hemostatic drugs chemically. • Explains chemical classes of drugs. • Names antifibrinolytic drugs chemically. • Explains the chemical structure of antifibrinolytic drugs. • Explains synthesis methods of antifibrinolytic drugs. • Names vitamin K and its analogs chemically. • Explains the chemical structure of vitamin K and its analogues. • Explains the synthesis of vitamin K and its analogs. • Names ther haemostatic drugs chemically. • Explains the chemical structure of other drugs with hemostatic effect. • Classifies the anticoagulant drugs chemically. • Explains chemical classes of drugs. • Names coumarin derivatives chemically. • Explains chemical structure of coumarin derivatives. • Describes synthesis of coumarin derivatives. • Explains the biotransformation of coumarin derivatives. • Explains the structure-activity relationships of coumarin derivatives. • Names indanon derivatives chemically. • Explains the chemical structure of indanon derivatives. • Describes the synthesis of indanon derivatives. • Explains the structure-effect relationships of indanon derivatives. • Names anticoagulant drugs chemically. • Expands the chemical structures of other anticoagulant drugs. • Explains the synthesis of other anticoagulant drugs. • Names antiplatelet drugs chemically. • Explains chemical classes of drugs. • Open the chemical structure of antithrombocytic drugs. • Explains the synthesis of antithrombocytic drugs. • Explains the chemical structure of antithrombocytic drugs. • Explains the chemical structure of thrombolytic drugs. • Explains the chemical structures of antianemic drugs. • Expands the chemical structure of the compounds that replace plasma. • Explains the chemical structure of drugs used in water and electrolyte balance disorders. • Explains the chemical structures of drugs used in acid-base balance disorders.
Will be able to Evaluate Herbal Drugs Related to Cardiovascular and Urinary Systems.
• Lists antihypertensive drugs. • Lists the general characteristics of antihypertensive drugs. • Lists effective compounds of antihypertensive drugs. • Explains the use and dose of antihypertensive drugs. • Explains the issues to be considered in the use of antihypertensive drugs. • Lists peripheral vasodilator effective drugs. • Lists the general properties of peripheral vasodilator drugs. • Lists the effective compounds of peripheral vasodilator drugs. • Explains the use and dosage of peripheral vasodilator drugs. • Explains the importance of peripheral vasodilator drugs. • Lists the antianginal effective drugs. • Lists general characteristics of antianginal drugs. • Lists effective compounds of antianginal drugs. • Explains the use and dosage of antianginal drugs. • Explains the issues to be considered in the use of antianginal drugs. • Lists the antiarrhythmic effective drugs. • Lists the general properties of antiarrhythmic effective drugs. • Lists effective compounds of antiarrhythmic effective drugs. • Explains the use and dose of antiarrhythmic drugs. • Explains the issues to be considered in the use of antiarrhythmic drugs. • Lists effective drugs for heart failure. • Lists the general characteristics of drugs effective on heart failure. • Lists the effective compounds of drugs effective on heart failure • Explains the use and dose of drugs effective on heart failure. • Explains the issues to be considered in the use of drugs effective on heart failure. • Lists the β-adrenergic receptor blocker-acting drugs. • Lists the general characteristics of β-adrenergic receptor blocker-acting drugs. • Lists the effective compounds of β-Adrenergic receptor blocker-acting drugs. • Explains the use and dose of β-adrenergic receptor blocker-acting drugs. • Explains the importance of β-adrenergic receptor blocker drugs • Lists the drugs with hypolipidemic effect. • Lists general characteristics of hypolipidemic drugs. • Lists effective compounds of hypolipidemic drugs. • Explains the use and dosage of hypolipidemic drugs. • Explains the issues to be considered in the use of hypolipidemic drugs • Lists antithrombotic drugs. • Lists the general characteristics of antithrombotic drugs. • Lists the effective compounds of antithrombotic drugs. • Explains the use and dose of antithrombotic drugs. • Explains the issues to be considered in the use of antithrombotic drugs. • Lists hemostatic drugs. • Lists the general characteristics of hemostatic drugs. • Lists the effective compounds of hemostatic drugs. • Explains the use and dosage of hemostatic drugs. • Explains the issues to be considered in the use of hemostatic drugs. • Lists antianemic drugs. • Lists general characteristics of antianemic drugs. • Lists effective compounds of antianemic drugs. • Explains the use and dose of antianemic drugs. • Explains the issues to be considered in the use of antianemic drugs. • Lists diuretic acting drugs. • Lists the general characteristics of diuretic drugs. • Lists the effective compounds of diuretic drugs. • Explains the use and dose of diuretic drugs. • Explains the issues to be considered in the use of diuretic drugs. • Lists the drugs affecting water and electrolyte balance. • Lists the general characteristics of drugs affecting water and electrolyte balance. • Lists the effective compounds of drugs affecting water and electrolyte balance. • Explains the use and dosage of drugs affecting water and electrolyte balance. • Explains the issues that should be considered in the use of drugs affecting water and electrolyte balance.
Will be able to Evaluate Quality Control Practices for Some Herbal Drugs; Synthesis, Analysis, Quality Control and Spectroscopy Practices of Some Pharmaceutical Compounds Related to Autonom, Cardiovascular and Urinary Systems.
• Determines the appropriate method for synthesis of the target compound. • Explains synthesis method of target compound. • Explains the reaction equation and mechanism of compound synthesis. • Lists the chemicals required for the synthesis of the target compound. • Explains the properties of chemical substances and their intended use for the synthesis of the target compound. • Describes the properties and uses of devices required for synthesis of target compound. • Explains reaction conditions of synthesis of target compound. • Synthesizes the target compound. • Terminates the reaction of the target compound according to the result of the TAC application. • Applies the filtration process to remove the synthesis product from the reaction medium. • Applies extraction process to remove the synthesis product from the reaction medium. • Explains the physical and chemical properties of the synthesis product. • Calculates the theoretical, practical and percent yield of the synthesis product. • Determines the suitable recrystallization solvent for the synthesis product. • Describes recrystallization of the synthesis product • Recrystallizes the synthesis product. • Lists the estimated IR data of the compounds of pharmaceutical importance. • Determines which functional groups belong to the bands observed in the IR spectra of the compounds of pharmaceutical importance. • Evaluates the structure by interpreting the IR spectra of the compounds of pharmaceutical importance. • Lists the estimated 1H NMR data of the compounds of pharmaceutical importance. • Determines the protons belong to the peaks observed in the 1H NMR spectra of the compounds of pharmaceutical importance. • Specifies the structure by interpreting the 1H NMR spectra of the compounds of pharmaceutical importance. • Lists the estimated MS data of pharmaceutical importance compounds. • Determines the parts belong to the peaks observed in the mass spectra of the compounds of pharmaceutical importance. • Determines molecular ion peak in mass spectra of compounds of pharmaceutical importance. • Determines the basic peak in the mass spectra of compounds of pharmaceutical importance. • Interprets mass spectra of compounds of pharmaceutical importance. • Evaluates the structure of an unknown molecule by interpreting IR, NMR and Mass spectra and other techniques of pharmaceutical importance compounds. • Distinguishes the sample by color, smell, taste and appearance. • Determines the melting point of the sample. • Determines the resolution class of sample. • Applies the burning test to the sample and interprets the results. • Determines the presence of nitrogen in the sample. • Detects the presence of sulfur in the sample. • Detects the presence of halogen in the sample. • Determines whether it is acidic, basic or neutral. • Distinguishes recognition tests of functional groups in the sample. • Explains the recognition tests of the functional groups in the sample. • Applies functional group recognition tests to the sample. • Identifies the specific diagnostic reaction that can be applied to the sample. • Performs a sample-specific diagnostic reaction. • Lists the titrimetric methods that can be applied to the sample. • Determines the purity of the sample by using the asymmetric method. • Determines the purity of the sample by using the alkalimetric method. • Determines the purity of the sample by using a nitriteometric method. • Determines the purity of the sample using the iodimetric method. • Detects the purity of the sample by spectrophotometric method specified in the pharmacopoeia.
Will be able to Evaluate Quality Control Practices for Some Herbal Drugs Related to Autonom, Cardiovascular and Urinary Systems.
• Applies macroscopic methods to a selected drug. • Applies organoleptic methods to a selected drug. • Evaluates the results of macroscopic and organoleptic analysis for a selected drug. • Lists the appropriate reagents in order to examine a selected stain by microscopic methods. • Uses the assignment key to examine a selected micrograph by microscopic methods. • Examines a selected drug microscopically. • Evaluates the results of a microscopic examination. • Explains the foreign matter quantification method for a selected drug. • Evaluates the results in terms of limit values by calculating the amount of foreign matter for a selected drug. • Lists the physicochemical methods required for a selected drug. • Explains the process steps of physicochemical methods for a selected drug. • Determines the results of the physicochemical method required for a selected drug. • Compares the results of the physicochemical method required for a selected drug with the limit values. • Lists the appropriate extraction methods for target active substances in a selected drug. • Describes the extraction steps for a selected drug. • Applies the appropriate extraction method for the target active substances in a selected drug. • Lists the appropriate diagnostic reactions for the target active substances in a selected drug. • Describes the processing steps for the appropriate diagnostic reactions for the target active substances in a selected drug. • Evaluates the appropriate diagnostic reaction results for target active substances in a selected drug. • Lists the appropriate chromatographic analysis methods for target active substances in a selected drug. • Describes the appropriate chromatographic analysis steps for the target active substances in a selected drug. • Applies suitable chromatographic methods for target active substances in a selected drug. • Evaluates the results of suitable chromatographic methods for target active substances in a selected drug. • Lists the adulteration determinations indicated in the Pharmacope for a selected drug. • Describes the process steps to determine adulteration in a selected drug. • Determines adulterations in a selected drug. • Lists the pharmacognosy methods in pharmacopoeia for a selected drug. • Explains the process steps of pharmacognosy methods for a selected drug. • Applies the pharmacognosy methods in pharmacotherapy for a selected drug. • Compares the results obtained for a selected drug to the pharmacopeia. • Interprets and evaluates all the results obtained for a selected drug.